Tag: hunter gatherers

Rapid human genetic changes after the last Ice Age

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Our hominin ancestors in Africa first fashioned tools about 3.5 Ma ago. Since then regular intake of animal protein through hunting, followed by the later discovery of fire and cooking, may progressively have encouraged the evolution of larger hominin brains. Both behavioural leaps would have reduced the length of the ‘working day’ needed to sustain hominin groups. That would have lengthened opportunities for cognitive reflection. social life and culture, and thus further evolution. They also expanded the opportunities for migration, beginning with Homo ergaster venturing beyond Africa at least 1.8 Ma ago. Hominins evolved to such an extent that several separate species occupied our home world at any one time until about 45 thousand years ago. After that only H. sapiens occupied Africa, Eurasia and Australasia.

Such protracted and meandering evolution and dispersal clearly involved episodic physiological and cultural changes, but all we have to go on are fragmentary fossil remains and artifacts of various kinds. DNA has yet to be extracted from hominin bones older than 400 ka (an early Neanderthal from northern Spain). Though H. sapiens first appeared in Morocco about 300 ka ago, DNA from our species dates back to only 45 ka (western and central Europe). What is today termed ‘ancient’ human DNA, is actually very young and restricted to climate zones where its decomposition has been slow. At present there is little point in analysing fossil material from tropical and subtropical latitudes; the DNA is degraded beyond recovery by even the most up-to-date techniques. Fascinating as discussion of human evolution is, in reality most is merely inferred from comparative anatomy and anthropological interpretation.

By 45 ka the heavy evolutionary lifting had been done, resulting in anatomically modern humans, but we have little, if any, chance of explaining in genetic terms how it was achieved. There has been much speculation about the conditions, particularly climatic ones, which may have driven the changes. During the last 2.6 Ma – the Quaternary Period – global climate has been the most changeable in the last 300 Ma. Ice ages have come and gone, first in 40 ka cycles and during the last million years every 100 ka. Much more rapid changes, such as millennial Dansgaard-Oeschger cycles, appeared during each glacial episode, the last being the Younger Dryas between 12.9 and 11.7 ka. For a long while ideas on the drivers of human evolution have been dominated by those concerning environmental stress. Unsurprisingly, genetic change has also been ascribed to such a Darwinian-ecological cause: adaptability to adversity. To test such a hypothesis requires genetic data, of course. But, except for the climatically more stable Holocene Epoch since 11.7 ka, ancient human genomes are in very short supply.

Renowned researcher into ancient human genetics David Reich of the Harvard Medical School in Boston, USA has collated more than 15 thousand ancient human genomes extracted from the remains of individuals who lived and died in Europe and parts of the Middle East during the last ten thousand years. These have been analysed statistically in the context of ‘directional selection’. This is a type of natural selection that occurs when one version of a gene – an allele – confers an extreme form of a trait. If it proves advantageous it rapidly gets passed on to more descendants than do less advantageous alleles, and thus rises in frequency across a population. This differs from other causes of gene frequency changes, such as human migration, population mixing, and random genetic fluctuations that occur in small populations. Well-known examples of directional selection are rapid changes among European Peppered moths, African cichlid fish, Alaskan Sockeye salmon and Big Cats which change over time in response to variations in their habitats. A human example is a genetic variant that maintains the ability to digest the sugar lactose in milk beyond infancy, which enables many modern Europeans to digest milk throughout their lives. The algorithm needed to separate signs of directional selection from other types of genetic change was developed by Ali Akbari, a computational geneticist also at Harvard Medical School. A recent paper by Akbari, Reich and colleagues in the US, Iran, Germany, and Austria (Akbari, A. and 15 others 2026. Ancient DNA reveals pervasive directional selection across West Eurasia. Nature, advance online publication; DOI: 10.1038/s41586-026-10358-1) seems set dramatically to change the research into recent human evolutionary genetics.

Akbari et al. discovered that directional selection has driven the spread or decline of hundreds of gene variants in human populations throughout Western Europe in the last ten millennia. In particular, selection accelerated with the adoption of farming rather than a hunter-gatherer lifestyle.  Among the gene variants are those connected with light skin, red hair, risk of celiac disease – linked to gluten in cereals –  susceptibility to gout, resistance to leprosy, baldness, rheumatoid arthritis and alcoholism. There are many more (see Figure 3 in the paper): the team identified 479 gene variants affected by directional selection, some that can be explained by changes in lifestyle, others less explicable and yet more that underlie complex traits such as mental illness and cognition. Some of the variants sprang up and were sustained in the population, others rose and then dwindled. The Neolithic began a period of fundamental life style changes in Europe, summed up as a shift from hunting and foraging to farming of cereals and livestock, as early as about 10 ka ago in what is now Türkiye. The pace of genetic changes of this kind reached a peak around the Bronze Age, perhaps because human activities in Europe became more complex then with the mass migration westwards of Yamnaya horse- and wagon-using people from the steppes to dominate Europe

The shift from small wandering bands to living in settlements was a drastic change from a lifestyle that had continued throughout all previous human history. So, it is hardly surprising that there was a major shift in humans’ genetic makeup. But such a change in human labour was not unique to Europe and is known to have occurred on all inhabited continents, with the exception of Australia, at different times during the Holocene. Other regional genetic databases can be analysed in much the same way, once sufficient ancient DNA is collected in Asia, Africa and the Americas. Yet not much is available. The authors comment: ‘A variant that now correlates to household income or years of schooling [remarkably, there are some!] had to have meant something different in the Stone Age. So these results do not mean that Europeans evolved to be smarter or healthier.’  Moreover, the research results in the paper seem likely to be amplified as the data set is so large and complex.

See also: Dutchen, S. et al. 2026. Massive Ancient-DNA Study Reveals Natural Selection Has Accelerated in Recent Human Evolution. Harvard Medical School: News & Events. 15 April 2026; Callaway, E. 2026. Landmark ancient-genome study shows surprise acceleration of human evolution. Nature, v. 652, News, 15 April 2026

Evolution of pigmentation in anatomically modern humans of Europe: a new paradigm?

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The colours of human skin, eyes and hair in living people across the world are determined by variants of genes (alleles) found at the same place on a chromosome. Since chromosomes are inherited from both mother and father, an individual may have the same two alleles (homozygous), or one of each (heterozygous). A dominant allele is always expressed, even if a single copy is present. A recessive allele is only expressed if the individual inherits two copies of it. Most characteristics of individuals result from the interaction of multiple genes, rather than a single gene. A commonly cited example is the coloration of eyes. If we had a single gene for eye colour – that of the iris – that had alleles just for blue (recessive or ‘b’) and one for brown (dominant or ‘B) pigmentation, brown-eyed individuals would have one or two ‘B’ alleles (bB or BB), whereas those with blue eyes would have to have two ‘blue’ alleles (bb). But inheritance is more complicated than that: there are people with green, hazel or grey eyes and even left- and right eyes of different colour. Such examples suggest that there are more than two genes affecting human eye colour, and each must have evolved as a result of mutations. Much the same goes for hair and skin coloration.

A group of scientists from the University of Ferrara in Italy have analysed highly detailed ancient DNA in anatomically modern human remains from Russia (Palaeolithic), Sweden (Mesolithic) and Croatia (Neolithic) to tease out the complexities of pigmentation inheritance. Then they applied a statistical approach learned from that study to predict the likely skin-, eye- and hair pigmentation in 348 less detailed genomes of ancient individuals whose remains date back to 45 Ma ( Silvia Perretti et al, 2025. Inference of human pigmentation from ancient DNA by genotype likelihood. Proceedings of the National Academy of Science, v. 122, article e2502158122; DOI: 10.1073/pnas.2502158122).

An artist’s impression of a Mesolithic woman from southern Denmark (credit: Tom Bjorklund)

All the hunter-gatherer Palaeolithic individuals (12 samples between 45 and 13 ka old) bar one, showed clear signs of dark pigmentation in skin, eyes and hair – the outlier from Russia was probably lighter. Those from the Mesolithic (14 to 4 ka) showed that 11 out of 35 had a light eye colour (Northern Europe, France, and Serbia), but most retained the dark skin and hair expected in descendants of migrants from Africa. Only one 12 ka hunter-gatherer from Sweden had inferred blue eyes, blonde hair, and light skin.  The retention of dark pigmentation by European hunter-gatherers who migrated there from Africa has been noted before, using DNA from Mesolithic human remains and in one case from birch resin chewed by a Mesolithic woman. This called into question the hypothesis that high levels of melatonin in skin, which protects indigenous people in Africa from cancers, would result in their producing insufficient vitamin D for good health. That notion supposed that out-of-Africa migrants would quickly evolve paler skin coloration at higher latitudes. It is now known that diets rich in meat, nuts and fungi – staple for hunter-gatherers – provide sufficient vitamin-D for health at high latitudes. A more recent hypothesis is that pale skins may have evolved only after the widespread Neolithic adoption of farming when people came to rely on a diet dominated by cereals that are a poor source of vitamin-D.

However, 132 Neolithic farmers (10 to 4 ka ago) individuals studied by Perretti et al. showed increased diversity in pigmentation, with more frequent light skin tones, yet dark individuals persisted, particularly in southern and eastern Europe. Hair and eye colour showed considerable variability, the earliest sign of red hair showing up in Turkey. Even Copper- and Bronze Age samples ( 113 from 7 to 3 ka) and those from Iron Age Europeans (25 from 3 to 1.7 ka ago) still indicate common retention of dark skin, eyes and hair, although the proportion of lighter pigmentation increased in some regions of Europe. Other analyses of ancient DNA have shown that the Palaeo- and Mesolithic populations of Europe were quickly outnumbered by influx of early farmers, probably from the Anatolian region of modern Turkey, during the Neolithic. The farming lifestyle seems likely to have allowed the numbers of those who practised it to rise beyond the natural environment’s ‘carrying capacity’ for hunter-gatherers. The former inhabitants of Europe may simply have been genetically absorbed within the growing population of farmers. Much the same absorption of earlier groups seems to have happened with the westward migration from the Ukrainian and Russia steppes of the Yamnaya people and culture, culminating in the start of the European Bronze Age that reached western Europe around 2.1 ka, The Yamnaya introduced metal culture, horse-drawn wheeled vehicles and possibly Indo-European language.

So the novel probabilistic approach to ancient DNA by Perretti et al. also casts doubt on the diet-based evolution of light pigmentation at high latitudes. Instead, pulses of large population movements and thus changes in European population genetics probably account for the persistence of abundant evidence for dark pigmentation throughout Europe until historic times. The ‘lightening’ of Europeans’ physiognomy seems to have been vastly more complex than previously believed. Early Europe seems to have been almost bewilderingly diverse, which make a complete mockery of modern chauvinism and racism. The present European genetic ‘melting pot’ is surprisingly similar to that of Europe’s ancient past.